Affiliation:
1. ALS Center, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale 28100
Novara, Italy
2. Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale
28100, Novara, Italy
Abstract
Background:
The management of neurodegenerative diseases can be frustrating for clinicians,
given the limited progress of conventional medicine in this context.
Aim:
For this reason, a more comprehensive, integrative approach is urgently needed. Among various
emerging focuses for intervention, the modulation of central nervous system energetics, oxidative
stress, and inflammation is becoming more and more promising.
Methods:
In particular, electrons leakage involved in the mitochondrial energetics can generate reactive
oxygen-free radical-related mitochondrial dysfunction that would contribute to the etiopathology
of many disorders, such as Alzheimer's and other dementias, Parkinson's disease, multiple sclerosis,
stroke, and amyotrophic lateral sclerosis (ALS).
Results:
In this context, using agents, like acetyl L-carnitine (ALCAR), provides mitochondrial support,
reduces oxidative stress, and improves synaptic transmission.
Conclusion:
This narrative review aims to update the existing literature on ALCAR molecular profile,
tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,General Neuroscience
Cited by
3 articles.
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