A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases-Reference-Cited by-同舟云学术

A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases

Published:2019-03-18 Issue:2 Volume:18 Page:103-114
ISSN:1871-5273
Container-title:CNS & Neurological Disorders - Drug Targets
language:en
Short-container-title:CNSNDDT

Author:

Zhao Jia¹,Zhu Mengxia¹,Kumar Mukesh¹,Ngo Fung Yin¹,Li Yinghui¹,Lao Lixing¹,Rong Jianhui¹

Affiliation:

1. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China

Abstract

Background & Objective: Alzheimer’s disease (AD) and Parkinson’s disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms. Conclusion: This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.

Funder

Health and Medical Research Fund

National Natural Science Foundation of China

General Research Fund (GRF)

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,General Neuroscience

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