The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review-Reference-Cited by-同舟云学术

The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review

Published:2023-10-24 Issue: Volume:16 Page:
ISSN:1874-4710
Container-title:Current Radiopharmaceuticals
language:en
Short-container-title:CRP

Author:

Klunko Natalia S.¹,Achmad Harun²,Abdullah Tamara Muayad³,Mohammed Sami⁴,Saha Indranil⁵,Salim Khulood Saadoon⁶,Obaid Rasha Fadhel⁷,Romero-Parra Rosario Mireya⁸,Al-Hasnawi Shaker Shanawa⁹,Al-janabi Wissam Hamid¹⁰,Farhood Bagher¹¹^ORCID

Affiliation:

1. Department of Training of Scientific and Scientific-Pedagogical Personnel, Russian New University, Moscow, Russia

2. Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia

3. Department of Radiology and Sonar Techniques, Al-Noor University College, Nineveh, Iraq

4. Medical Technical College, Al-Farahidi University, Baghdad, Iraq

5. Department of Physics, GLA University, Mathura, Pin- 281406, U.P., India

6. College of Pharmacology Pharmacy, Al-Bayan University, Baghdad, Iraq

7. Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq

8. Department of General Studies, Universidad Continental, Lima, Perú

9. College of Pharmacy, the Islamic University, 54001 Najaf, Iraq

10. Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq

11. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran

Abstract

Abstract: Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Radiology, Nuclear Medicine and imaging