Affiliation:
1. College of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Abstract
Abstract:
Cardio-cerebrovascular disease has seen a rapid rise in recent years, with Heart Failure
(HF) -- a terminal stage of various cardiovascular diseases -- also on the rise. HF has a complex
pathogenesis involving multiple factors, such as inflammation, fibrosis, and oxidative stress. Due
to its unique reverse shear mechanism, HF exhibits distinct expression patterns across different diseases.
CircRNA has been linked to conditions like cancer, diabetes, and osteoarthritis. This article
briefly introduces the mechanisms of circRNA biogenesis and its associated biological functions,
focusing on CircSLC8A1-1, CircRNA_000203, and others at the early stage of HF, CircRNA
PAN3, CircRNA (ACR), and others during the progression of HF, and CircHIPK3, CircNfix, and
others at the end stage of HF. These circRNAs play a participatory role in the exact mechanism.
As a research method, circRNA can be utilized to study the pathogenesis of heart failure and serve
as a target for drug discovery and development. Therefore, circRNA's ability to mark the disease
at different stages has significant guiding implications for HF monitoring, treatment, and prognosis.
Publisher
Bentham Science Publishers Ltd.