Affiliation:
1. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2. Department of
Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology,
Beijing, China
Abstract
Abstract:
The rapid and accurate identification of pathogens plays a crucial role in clinical practice,
which helps to prevent, control, and treat pathogenic infections at the initial stage. The current available
technologies for pathogen detection appear to be inadequate in dealing with cases such as COVID-19.
More importantly, the frequent emergence of drug-resistant bacteria is gradually rendering the existing
therapeutic options ineffective. Efforts are urgently required to focus on the development of diagnostic
systems for point-of-care (POC) detection and high-throughput pathogen identification. Since 2001, a
new class of aggregation-induced emission luminogens (AIEgens) with good photostability, high sensitivity,
and improved signal-to-noise ratio has emerged as powerful fluorescent tools for various biosensing
and cell imaging. Based on the unique fluorescence of AIEgens that becomes stronger upon aggregation,
naked-eye detection in turn-on mode has gained a speedy development. A timely overview can not only
provide a summary of the advances and challenges of AIEgens in pathogen detection but also offer systematic
ideas for future developments. There are also expectations for in-depth interdisciplinary research
in the field of analytical chemistry and microbiology.
Funder
Beijing Natural Science Foundation
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Double Ph.D. Program of Jiangsu Province
Green Yang and Gold Golden Phoenix Plan of Yangzhou City
Yangzhou University Interdisciplinary Research Foundation for Chemistry Discipline of Targeted Support
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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