Affiliation:
1. Department of cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey
2. Department of cardiology, Kahta State Hospital, Turkey
Abstract
:
Serum resistin, mainly secreted by the bone marrow, monocytes, and macrophages, contributes to many processes, including endothelial dysfunction, vascular smooth muscle cell (VSMC) proliferation, and atherothrombosis demonstrating effects on the development of hypertension and coronary artery disease (CAD). Previously published clinical studies have shown that plasma resistin levels are significantly associated with cardiovascular disease risk factors and adverse clinical outcomes associated with the condition. Resistin is associated with vascular smooth muscle cell dysfunction in vitro, most plausibly due to its relationship with oxidative stress in advanced atherosclerosis, whereas in vivo studies have shown resistin to be associated with intimal hyperplasia. We aimed to summarize the role of resistin on cardiovascular disease (CVD), as we could not find any review focused on the role of resistin on CVD.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,General Medicine
Cited by
9 articles.
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