Biological Therapies for Pediatric Atopic Dermatitis - A Review-Reference-Cited by-同舟云学术

Biological Therapies for Pediatric Atopic Dermatitis - A Review

Published:2024-08 Issue:3 Volume:20 Page:240-252
ISSN:1573-3963
Container-title:Current Pediatric Reviews
language:en
Short-container-title:CPR

Author:

Milano Giulia¹,Forestieri Stefano²,Tedeschi Micol³,Licari Amelia³⁴^ORCID,Brazzelli Valeria⁵⁶,Marseglia Gian Luigi³⁴^ORCID

Affiliation:

1. Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy

2. School of Pediatrics, University of Cagliari, Cagliari, Italy

3. Pediatric Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy

4. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

5. Department of Clinical-Surgical, Diagnostic and Pediatric Science, University of Pavia, Pavia, Italy

6. Dermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Abstract

Abstract: Atopic dermatitis (AD) is the most frequent chronic-recurrent inflammatory skin disease in the pediatric age. It has a complex and multifactorial pathogenesis: the two key actors are im- paired skin barrier function and immune system dysregulation, which represent the main targets of AD therapy. Monoclonal antibodies have revolutionized the management of moderate-to-severe AD, by selective inhibition of key cytokines in the pathogenetic process. For this reason, there is great interest in exploring AD pathogenetic mechanisms to develop new therapeutic strategies. This review aims to summarize the most recent scientific evidence on available and future biologi- cal therapies for the treatment of pediatric AD, emphasizing the molecular mechanisms underlying their action.

Publisher

Bentham Science Publishers Ltd.

Subject

Pediatrics, Perinatology and Child Health