Beta Thalassemia Carrier Rate: Problem Burden among High School Children-Reference-Cited by-同舟云学术

Beta Thalassemia Carrier Rate: Problem Burden among High School Children

Published:2023-05 Issue:2 Volume:19 Page:203-209
ISSN:1573-3963
Container-title:Current Pediatric Reviews
language:en
Short-container-title:CPR

Author:

Sherief Laila M.¹,El-Shanshory Mohamed R.²,Yahia Sohier³,Ragab Seham M.⁴,Mansour Ahmed K.³⁵,Hassab Hoda M.⁶,Hesham Mervat A.¹,Ahmed Adel S.¹,Beshir Mohamed R.¹,El Fotoh Wafaa M. Abo⁴,El Naby Sameh A. Abd⁴,Alllah Ahmed M. Gad⁷,Khalifa Naglaa A.⁷,Soliman Mohamed A.⁸,El-Dahtory Faeza⁹,El-Farahaty Reham M.¹⁰,Osman Engy³,Elhabyan Abdelazeem¹¹,El-Lateef Amal E. Abd¹²,Kamal Naglaa M.¹³,Kabbash Ibrahim A.¹⁴,Saied Shimaa M.¹⁴,Eid Abdel-Rahman³

Affiliation:

1. Pediatric Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2. Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt

3. Pediatric Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt

4. Pediatric Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

5. Faculty of Medicine, Delta University for Science and Technology, Tanta, Egypt

6. Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

7. Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

8. Clinical Pathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

9. Consultant of Biochemistry, Genetic Unit, Children Hospital, Mansoura University, Dakahlia, Egypt

10. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt

11. Faculty of Medicine, Tanta University, Tanta, Egypt

12. Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

13. Pediatric Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

14. Faculty of Medicine, Tanta University, Public Health, and Community Medicine Department, Tanta, Egypt

Abstract

Background & Aim of the work: β-Thalassemia (βT) is highly prevalent in some countries like Egypt. Accurate data about actual disease prevalence and heavily prevalent geographic locations are essential to help in early detection and in setting up effective preventive programs. We aim for screening of βT carriers among Egyptian high school students in the Delta region. Subjects and Methods: A cross-sectional multicenter study was carried on 4320 randomly selected students from four governorates of the Nile Delta region, Egypt. All patients were to be tested for their complete blood count. Those with microcytic hypochromic anemia not caused by iron deficiency were tested for βT carrier status using high-performance liquid chromatography. Results: The total prevalence of βT carrier rate was 6.13%. The highest prevalence was detected in Al-Sharkia Governorate, reaching 7.89%, followed by 6.90% in Al-Gharbia Governorate. Al-Dakahilia and Al-Menoufia showed lower rates of 4.86% and 3.73%, respectively. Conclusions: Despite the premarital national screening program for βT in Egypt, the carrier rate is still high. More effort should be done for the proper implementation of national prevention programs.

Funder

Science, Technology and Development Fund

Publisher

Bentham Science Publishers Ltd.

Subject

Pediatrics, Perinatology and Child Health

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