Effects of Consuming Catha Edulis Forsk (khat)on the Gene Manifestation of CHRM1 and CHRM3 in relation to Salivary Glands, Saliva Flow Rates, pH and Dental Caries in Yemeni Consumers

Author:

Alshahrani Sawsan Abdullah,Almufareh Nawaf Abdulrahman,Almarshady Bandary,Alotaibi Rasil Khaled,Al-Qahtani Wedad Saeed

Abstract

Background:The current study has been conducted to estimate the impact of Catha Edulis Forsk (simply known as khat) on pH and saliva flow rate in teeth unaffected by caries among patients from Arab, Yemen, consuming the plant. The goal was to evaluate the relation of these indicators with gene manifestation ofCHRM1andCHRM3,which contributes to the regulation of saliva secretions.Methods:Overall, 60 respondents aged between 27 and 54 years were selected for the research. They were distributed among two groups, group I and group II, including 30 respondents equally. Group I incorporated respondents consuming no khat, having teeth caries, adequate saliva flow, and generally, healthy oral cavity. In turn, group II incorporated respondents consuming khat having caries-free teeth, inadequate saliva flow and relatively unhealthy oral cavity. Saliva samples were taken from all respondents. They were analyzed for indicators of flow rate as well as pH of saliva. Salivary gland biopsy specimens have also been taken. The whole RNA was allocated, cDNA synthesized and reinforced to estimate the gene manifestation ofCHRM1andCHRM3.Results:A considerable rise in the mean salivary flow rate along with a drastic decline in the mean salivary pH within caries-free teeth among the respondents consuming khat was observed during the study. The mRNA expressionsCHRM1andCHRM3were significantly increased among participants consuming khat. Results were contrasted to the control group of patients not consuming khat.Conclusion:The characteristics of salivary flow rate, pH, and caries-free teeth have been related to the gene manifestations ofCHRM1andCHRM3in respondents consuming khat.

Publisher

Bentham Science Publishers Ltd.

Subject

General Dentistry

Reference25 articles.

1. Begun A L. Introduction to psychoactive substances 2020.

2. Touger-Decker R, van Loveren C. Sugars and dental caries. Am J Clin Nutr 2003; 78 (4) : 881S-92S.

3. Soesilawati P, Notopuro H, Yuliati Y, Ariani MD, Alwino Bayu Firdauzy M. The role of salivary sIgA as protection for dental caries activity in Indonesian children. Clin Cosmet Investig Dent 2019; 11 : 291-5.

4. Devarajan H, Somasundaram S. Salivary proteins and its effects on dental cariesL: A review. Drug Invention Today 2019.

5. Maheswari E, Kumar R P, Arumugham I M, Sakthi D S, Lakshmi T. Evaluation of salivary flow rate, pH, buffering capacity, total calcium, protein, and total antioxidant capacity level among caries-free and caries-active children: A systematic review. Journal of Advanced Pharmacy Education and Research 2017; 7 (2)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3