Decoding and Unravelling Mpox, Herpes, and Syphilis Infections: A State of Art Review

Author:

Wang Jiao1,Goyal Rajat2,Gautam Rupesh K.13,Garg Kajal45,Husain Shaheen6,Chopra Hitesh7,Dubey Ankit Kumar18,Rayan Rehab A.9,Kamal Mohammad Amjad11011,Mishra Dinesh Kumar3,Gundamaraju Rohit1213,Shen Bairong1,Singla Rajeev K.1ORCID

Affiliation:

1. Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China

2. MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India-133207

3. Indore Institute of Pharmacy, Rau, Indore, India-453331

4. Lal Chand Mal College of Education, Jhansa, Kurukshetra (c)-136130, India

5. SD (PG) College Panipat, Haryana 132103, India

6. Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, UP, India

7. Chitkara College of Pharmacy, Chitkara University, Punjab, India-140401

8. iGlobal Research and Publishing Foundation, New Delhi, India

9. Department of Epidemiology, High Institute of Public Health, Alexandria University, Egypt-5422031

10. King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia

11. Enzymoics, 7 Peterlee Place, Hebersham NSW 2770; Novel Global Community Educational Foundation, Australia

12. ER stress and mucosal immunology lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia

13. School of Medicine, University of California San Francisco, San Francisco, California, United States of America

Abstract

As the world recovers from the COVID-19 pandemic, a resurgence in MPXV cases is causing serious concern. The early clinical similarity of MPXV to common ailments like the flu and cold, coupled with the resemblances of its progressing rash to other infections, underscores the importance of prompt and accurate diagnosis. Among the infections, smallpox is clinically closest to MPXV, and rashes similar to MPXV stages also appear in syphilis and varicella zoster. A comprehensive review of MPXV, herpes, and syphilis was carried out, including structural and morphological features, origins, transmission modes, and computational studies. PubMed literature search on MPXV, using MeSH key terms, yielded 1904 results, with the analysis revealing prominent links to sexually transmitted diseases. More in-depth exploration of MPXV, Herpes Simplex Virus (HSV), and Syphilis revealed further disease interconnections and geographical correlations. These findings emphasize the need for a holistic understanding of these interconnected infectious agents for better control and management.

Publisher

Bentham Science Publishers Ltd.

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