Affiliation:
1. First College of Clinical Medicine, Hebei North University, Zhangjiakou 075000, China
2. First Hospital of Qinhuangdao
Affiliated to Hebei North University, Qinhuangdao 066000, P.R. China
3. Breast Disease Diagnosis and Treatment
Center, First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province 066000, P.R. China
Abstract
:
Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological
activities, and their disorders or imbalances can lead to various diseases. As a subgroup of
deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many
biological processes. USP53, one of the family members, is widely expressed in human tissues and
participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling.
Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential
cause of schizophrenia. Knockout of USP53 can alleviate neuropathic pain induced by
chronic constriction injury. Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis
and functional activity of osteoclasts, and triggers osteodestructive diseases. USP53 plays a
tumor-suppressive role in lung cancer, renal clear cell carcinoma, colorectal cancer, liver cancer,
and esophageal cancer but reduces the radiosensitivity of cervical cancer and esophageal cancer to
induce radioresistance. Through the in-depth combination of literature and bioinformatics, this review
suggested that USP53 may be a good potential biomarker or therapeutic target for diseases.
Publisher
Bentham Science Publishers Ltd.