Significant Interaction between Melatonin and Titanium Bone Implants: Available Evidence and Future Research Directions-Reference-Cited by-同舟云学术

Significant Interaction between Melatonin and Titanium Bone Implants: Available Evidence and Future Research Directions

Published:2024-06-25 Issue: Volume:25 Page:
ISSN:1389-2010
Container-title:Current Pharmaceutical Biotechnology
language:en
Short-container-title:CPB

Author:

Hosseinzadeh Azam¹,Bagherifard Abolfazl²,Sheibani Mohammad³,Karimi-Behnagh Arman⁴,Reiter Russel J⁵,Mehrzadi Saeed¹

Affiliation:

1. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran

2. Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

3. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

4. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

5. Department of Cell Systems and Anatomy, UT Health San Antonio, Long School of Medicine, San Antonio, TX, USA

Abstract

Abstract: The trend in the incidence rate of bone fractures has been upward and as a result, the burden associated with orthopedic fractures has increased significantly. Titanium (Ti) implants are considered a preferred method of managing long bone fractures. However, no benefit comes without some downside, and using Ti implants is associated with several complications. In this respect, it was observed that in bones, Ti can disrupt the bone healing process by disturbing the balance of osteoclast and osteoblast activation and also increasing the production of inflammatory cytokines. Melatonin is a widely-acting molecule that possesses strong anti-oxidant features. This molecule reinforces mineral density and improves bone formation processes. In this review, we focused on the protective effect of melatonin in mitigating the Ti-related complications.

Publisher

Bentham Science Publishers Ltd.