Affiliation:
1. Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, P.R. China
2. National Anti-Tumor Natural Drug Engineering Research Center of Ministry of Education of Harbin University of
Commerce, Harbin, P.R. China
3. Harbin Institute of Technology, No.92 Xidazhi Street, Nangang District, Harbin
150001, P.R. China
Abstract
Abstract::
Indole alkaloids are a class of secondary metabolites with a wide range of biological activities.
The chemical structure of indole alkaloids is relatively complex, but all of them have a remarkable
structural feature, which is a five-membered pyrrole cyclocyclobenzene ring. Because of
the unique structural characteristics of indole alkaloids, they have also a wide range of pharmacological
activities, such as antibacterial, anti-inflammatory, anti-tumor, anti-viral, anti-hepatitis, antidiabetes,
neuroprotective, lipid-lowering and so on. For example, indole alkaloids have been shown
to show anticancer activity through various anti-proliferation mechanisms and play an important
role in the research of novel cancer treatment advances. In this article, we reviewed the recent progress
of indole alkaloids isolated from microorganisms and their chemical and biosynthesis, which
laid a foundation for further utilization and development of indole alkaloids.
Publisher
Bentham Science Publishers Ltd.