Affiliation:
1. Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, P.R. China
2. National Anti-tumor Natural Drug Engineering Research Center of Ministry of Education of Harbin University of Commerce, Harbin, China
3. Harbin Institute of Technology, No. 92 Xidazhi Street, Nangang District, Harbin 150001, P.R. China
Abstract
Abstract:
The imidazole ring is a five membered ring with a simple chemical structure and is widely
present in natural products. Due to its unique chemical structure, it is beneficial for the imidazole
ring to bind with other functional groups, thus exhibiting a wide range of biological activities. The
synthesis of imidazole derivatives often involves the Debus method, Michael addition method, and
the use of existing materials to synthesize target compounds through one-pot synthesis. Imidazole
compounds have numerous medicinal properties and physiological activities, including antioxidant,
antibacterial, anti-inflammatory, antihistamine, hypoglycemic, antiviral, antihypertensive and anticancer
effects. In addition to its medicinal chemical significance, imidazole also has industrial applications
such as corrosion inhibitors, flame retardants, photography, and electronics. The synthesis
and activity research of imidazole and its derivatives have good development prospects. This article
reviews the chemical synthesis and biosynthesis of imidazole derivatives, as well as their biological
activities.
Publisher
Bentham Science Publishers Ltd.