A Sleeping rs-fMRI Study of Preschool Children with Autism Spectrum Disorders

Author:

Li Xiaomeng1,Wang Longlun2,Qin Bin2,Zhang Yun2,Zhou Zhiming1,Qin Yong2,Bao Guangcheng1,Huang Jie1,Cai Jinhua1ORCID

Affiliation:

1. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China

2. Department of Radiology, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China

Abstract

Objectives: The brain functional network of autism spectrum disorders (ASDs) in the earlier stages of life has been almost unknown due to difficulties in obtaining a resting-state functional magnetic resonance imaging (rs-fMRI). This study aimed to perform rs-MRI under a sedated sleep state and reveal possible alterations in the brain functional network. Methods: Rs-fMRI was performed in a group of preschool children (aged 2–6 years, 53 with ASD, 63 as controls) under a sedated sleeping state. Based on graph theoretical analysis, global and local topological metrics were calculated to investigate alterations in brain functional networks. Besides, correlation analyses were conducted between the abnormal attribute values and the Childhood Autism Rating Scale (CARS) scores. Results: The graph theoretical analysis showed that the nodal degree of the right medial frontal gyrus and the nodal efficiency of the right lingual gyrus in the ASD group were higher than those in the control group (P<0.05). There was a statistically significant positive correlation (R=0.318, P<0.05) between the right midfrontal gyrus nodal degree values and CARS scores in the ASD patients. Conclusion: Alterations of some nodal attributes in the brain network occurred in preschool autistic children which could serve as potential imaging biomarkers for evaluating ASD in earlier stages.

Funder

Chongqing Science and Technology Committee

Publisher

Bentham Science Publishers Ltd.

Subject

Radiology, Nuclear Medicine and imaging

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