Affiliation:
1. Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei Cancer Hospital, Hefei 230031, China
Abstract
Background::
It was known that the response of tumor cells to radiation is closely related
to tissue oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor
cells. Non-invasive mapping of tissue oxygen level may hold great importance in clinic.
Objective:
The aim of this study is to evaluate the role of oxygen-enhanced MR imaging in the
detection of tissue oxygen levels between fractionated radiotherapy.
Methods:
A cohort of 10 patients with brain metastasis was recruited. Quantitative oxygen enhanced
MR imaging was performed prior to, 30 minutes and 22 hours after first fractionated radiotherapy.
Results:
The ΔR1 (the difference of longitudinal relaxivity between 100% oxygen breathing and air
breathing) increased in the ipsilateral tumor site and normal tissue by 242% and 152%, respectively,
30 minutes after first fractionated radiation compared to pre-radiation levels. Significant recovery
of ΔR1 in the contralateral normal tissue (p < 0.05) was observed 22 hours compared to 30
minutes after radiation levels.
Conclusion:
R1-based oxygen-enhanced MR imaging may provide a sensitive endogenous marker
for oxygen changes in the brain tissue between fractionated radiotherapy.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Radiology, Nuclear Medicine and imaging
Cited by
5 articles.
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