Myxofibrosarcoma: Clinical and Prognostic Value of MRI Features

Author:

Spinnato Paolo1ORCID,Sambri Andrea2,Fujiwara Tomohiro3,Ceccarelli Luca1,Clinca Roberta1,Medellin Manuel R.4,Paolis Massimiliano De5,Donati Davide M.2ORCID,Bianchi Giuseppe2

Affiliation:

1. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

2. Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

3. Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

4. Istituto Nacional de Cancerologia, Bogota, Colombia

5. Department of Orthopaedics, AOSP Sant’Orsola Malpighi, Bologna, Italy

Abstract

Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma, which plays a key role in the preoperative setting of these patients. MRI features associated with the high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement and presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful in stratifying the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features.

Publisher

Bentham Science Publishers Ltd.

Subject

Radiology, Nuclear Medicine and imaging

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