A Case of Intracranial Space-occupying Lesion Caused by Infection of AIDS-associated Talaromyces Marnefei

Abstract

Background: Talaromyces marneffei (T. marneffei) is a heat-dimorphic fungus that commonly causes fatal opportunistic infections in immunocompromised patients, such as those with human immunodeficiency virus (HIV) infection. In this case report, Case Presentation: we describe a case of intracranial infection of T.marneffei in a 42-year-old AIDS patient. Contrast enhanced MRI showed the left occipital lobe mass with ring enhancement, MRS showed elevated AAs and Lip waves in the mass. Surgical resection of occipital lobe confirmed the lesion to be T.marneffei infection and possibly with tuberculosis after pathological examination. Patients with Intracranial ring enhancing space-occupying lesions on MRI should be considered of intracranial T. marneffei infection.Intracranial T.marneffei infection is relatively rare reported and recent studied. Conclusion: The MRI in this case suggests that ring enhancement mass and elevated AAs and Lip waves are helpful in the diagnosis of T.marneffei infection.