Affiliation:
1. Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Abstract
Wide exploration of noninvasive tumor/cancer biomarkers has shed light on
clinical diagnosis. However, many under-investigated biomarkers showed limited
application potency due to low sensitivity and specificity, while extracellular vehicles
(EVs) were gradually recognized as promising candidates. EVs are small vesicles
transporting bioactive cargos between cells in multiple physiological processes and also
in tumor/cancer pathogenesis. This review aimed to offer recent studies of EVs on
structure, classification, physiological functions, as well as changes in tumor initiation
and progression. Furthermore, we focused on advances of EVs and/or EV-related
substances in cancer diagnosis, and summarized ongoing studies of promising
candidates for future investigations.
Funder
Natural Science Foundation of Gansu Province
WBE Liver Fibrosis Foundation-Beijing Dongcheng District outstanding talent funding project
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
4 articles.
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