Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye-Reference-Cited by-同舟云学术

Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye

Published:2023-05 Issue:2 Volume:19 Page:180-188
ISSN:1573-3971
Container-title:Current Rheumatology Reviews
language:en
Short-container-title:CRR

Author:

Gheita Tamer A.¹^ORCID,ElAdle Suzan S.¹^ORCID,Latif Eiman Abdel²,Abdel-Fattah Yousra H.³^ORCID,Shebini Emad El⁴^ORCID,El-Gazzar Iman I.¹,El-Saadany Hanan M.⁵^ORCID,Samy Nermeen⁶^ORCID,El-Mallah Reem⁷,Salem Mohamed N.⁸^ORCID,Eesa Nahla¹^ORCID,Shereef Rawhya El⁹^ORCID,El Khalifa Marwa¹⁰^ORCID,Tharwat Samar¹¹^ORCID,Nasef Samah I.¹²^ORCID,Ibrahim Maha Emad¹²^ORCID,Khalil Noha M.¹³^ORCID,Abdalla Ahmed M.¹⁴,Abd Elazeem Mervat I.¹⁵^ORCID,Noor Rasha Abdel¹⁶^ORCID,Sallam Rehab¹⁷^ORCID,El-Bahnasawy Amany¹⁷^ORCID,Shanawany Amira El¹⁸^ORCID,Senara Soha¹⁹^ORCID,Fathi Hanan M.¹⁹^ORCID,Bakry Samah A. El⁶^ORCID,Elsaman Ahmed²⁰^ORCID,Najjar Amany El²¹^ORCID,Ragab Usama²²^ORCID,Talaat Esraa A.²³^ORCID,Hammam Nevin²³^ORCID,El-Hindawy Aya K.¹,Ismail Faten⁹

Affiliation:

1. Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

2. Ophthalmology Department, Faculty of Medicine, Alexandria University, Egypt

3. Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

4. Internal Medicine Department, Rheumatology Unit, Menoufia University, Menoufia, Egypt

5. Rheumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

6. Internal Medicine Department, Faculty of Medicine, Rheumatology Unit, Ain-Shams University, Cairo, Egypt

7. Rheumatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

8. Internal Medicine Department, Faculty of Medicine, Rheumatology Unit, Beni-Suef University, Beni-Suef, Egypt

9. Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt

10. Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt

11. Internal Medicine Department, Faculty of Medicine, Mansoura University, Rheumatology Unit, Dakahlia, Egypt

12. Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt

13. Internal Medicine Department, Faculty of Medicine, Cairo University, Rheumatology Unit, Cairo, Egypt

14. Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt

15. Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

16. Internal Medicine Department, Rheumatology Unit, Tanta University, Gharbia, Egypt

17. Rheumatology Department, Faculty of Medicine, Mansoura University, Dakahlia, Egypt

18. Rheumatology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

19. Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

20. Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt

21. Rheumatology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt

22. Internal Medicine Department, Clinical Immunology Unit, Zagazig University, Sharkia, Egypt

23. Rheumatology Department, Faculty of Medicine, Assuit University, Assuit, Egypt

Abstract

Background: Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pres-sure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear. Aims: The aim was to determine the frequency of MetS among BD patients and to study its relationship with disease characteristics. Methods: The study included 1028 adult BD patients recruited from 18 specialized rheumatology centers. 51 healthy matched control were considered. Behçet Disease Current Activity Form (BDCAF) and the BD damage index (BDI) were estimated. Adult Treatment Panel-III criteria were used to define MetS. Results: The mean age of patients was 36.8 ± 10.1 years, M:F 2.7:1 and disease duration 7.01 ± 5.2 years. Their mean BDCAF was 5.1 ± 4.6 and BDI 5.5 ± 2.8. MetS was present in 22.8% of patients and in 5.9% of control (3.9 fold higher-risk). Patients with MetS had a significantly increased age at onset (31.8 ± 9.2 vs. 29 ± 8.5 years) and higher frequency of genital ulcers (96.2% vs. 79.7%), skin involvement (73.1% vs. 50.4%), arthritis (48.3% vs. 29.1%) (p<0.0001) and CNS manifestations (18.8% vs. 13%) (p=0.042) compared to those without it. Eye involvement was significantly increased in those with MetS (82.1% vs. 74.2%) (p=0.003) with increased frequency of posterior uveitis (67.1% vs. 43.5%), retinal vessel occlusion (35.9% vs. 21.3%), retinal vasculitis (41.9% vs. 26.4%) (p<0.0001) and vitritis (37.2% vs. 24%) (p=0.001). BDCAF was significantly lower (3.9 ± 4.3 vs. 5.6 ± 4.6) and BDI higher (7.4 ± 2.7vs5 ± 2.6) (p<0.0001). Conclusion: BD patients with MetS are predisposed to mucocutaneous, musculoskeletal, neuropsychiatric and ocular manifestations with consequently increased damage. The involvement of the deeper structures of the eye should alarm rheumatologists to keep in mind that all patients should have an eye examination, especially those with MetS.

Publisher

Bentham Science Publishers Ltd.

Subject

Rheumatology

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pattern of uveitis in Behçet’s disease patients from a highly specialized university hospital-based tertiary care eye unit;The Egyptian Rheumatologist;2024-06

2. Modern determinants of cardiovascular risk factors in patients with psoriatic arthritis: Relation to disease activity and severity;The Egyptian Rheumatologist;2024-01

3. Association of Behçet’s disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis;Clinical and Experimental Medicine;2023-03-20