Affiliation:
1. Department of Immunology. Hospital Universitario Ramon y Cajal, Ctra. Colmenar Viejo, Km 9,100. C.P. 28034. Madrid, Spain
Abstract
Background:
Behçet’s Disease (BD, OMIM 109650) is a chronic relapsing inflammatory
disease of unknown etiology with unpredictable exacerbations and remissions. First described
in 1937 by the Turkish dermatologist HulusiBehçet, as a trisympton complex (oral and genital ulcers
and uveitis), it is now recognized as a multisystemic disease. The syndrome can manifest in
diverse ways and can involve nearly every organ system. Several studies have implicated T cells
and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock
proteins and streptococcal antigen. This article presents a review of the relevant published literature
about the immunopathogenesis of BD.
Result:
The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,”
“genetic”, “epigenetic”, “immunogenetic” or “immune response” to search the PubMed database.
All the relevant studies identified were included.
Publisher
Bentham Science Publishers Ltd.
Reference122 articles.
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2. Pay S.; Simşek I.; Erdem H.; Dinç A.; Immunopathogenesis of Behçet’s disease with special emphasize on the possible role of antigen presenting cells. Rheumatol Int 2007,27(5),417-424
3. Kulaber A.; Tugal-Tutkun I.; Yentür S.P.; Pro-inflammatory cellular immune response in Behçet’s disease. Rheumatol Int 2007,27(12),1113-1118
4. Dalvi S.R.; Yildirim R.; Yazici Y.; Behcet’s Syndrome. Drugs 2012,72(17),2223-2241
5. Mendoza-Pinto C.; García-Carrasco M.; Jiménez-Hernández M.; Etiopathogenesis of Behcet’s disease. Autoimmun Rev 2010,9(4),241-245
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