Affiliation:
1. Department of Autoimmune Diseases, Hospital Clínic, Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain
Abstract
Hospitalizations are frequent in Systemic Lupus Erythematosus (SLE) and carry a significant
economic burden. The focus of this review was to summarize the information available on the
main causes of SLE hospitalizations over recent decades. A literature review was conducted, using
PubMed and Scopus, for articles related to SLE hospital admissions from 1981 onward. Active disease/
flare and infection were the leading causes of admission across the study period. More recently,
other comorbidities gained relevance, such as cardio and cerebrovascular disease, pregnancy-related
morbidity, adverse drug reactions, thromboembolic events, malignancy and renal, pulmonary and
gastrointestinal disease. African and Southeast Asian studies seemed to display particularly high percentages
of patients admitted with active disease/flare, while European and North American studies
appeared to report more admissions due to comorbidities and accumulated disease/treatment damage.
Some data support a temporal change of certain admission causes, but the limited number, heterogeneity
and variance among studies weakens a consistent analysis. In conclusion, despite the developments
in SLE management, causes of hospitalization have not prominently changed across recent decades.
Publisher
Bentham Science Publishers Ltd.
Cited by
2 articles.
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