Association of Insulin Secretion Level on Lipid Fractions and Risk of Arterial Hypertension

Abstract

Background: The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension. Objective: This study evaluated the role of the insulin dosage and lipid fractions in the risk of arterial hypertension in type 2 diabetic patients in Western Algeria. Methods: This was a cross-sectional observational study involving 101 subjects with type 2 diabetes mellitus. The data collected was about the biodemographic profile of the participants. We performed multiple regressions to test the effect of insulin concentration on the parameters studied. Results: The multiple regression analytical study showed that HOMA-IR, BMI and waist circumference were predictors for the insulinemia response variable (P<0.05). It should be noted that in insulinopenia, insulin secretion is positively and significantly correlated with non-HDL-C (P=0.037), and it is also significantly and positively correlated with LDL-C (P=0.042). Multiple regression also shows that SBP and DBP are significantly and positively related to insulin resistance. Our data suggest a possible direct relationship between fasting insulin and blood pressure. Conclusion: Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics.