Interpreting the Mechanisms by which Integrins Promote the Differentiation of Mesenchymal Stem Cells and Integrin Application Prospects
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Published:2021-09-03
Issue:7
Volume:16
Page:848-857
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ISSN:1574-888X
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Container-title:Current Stem Cell Research & Therapy
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language:en
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Short-container-title:CSCR
Author:
Ying Liwei1,
Wang Chenggui1,
Shi Kesi1,
Zhou Xiaopeng1,
Gong Zhe1,
Shu Jiawei1,
Wang Jingkai1,
Xia Kaishun1,
Xiao Shining1,
Yu Chao1,
Yu Wei1,
Huang Xianpeng1,
Cheng Feng1,
Liang Chengzhen1,
Li Fangcai1,
Chen Qixin1
Affiliation:
1. Department of Orthopedics Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China
Abstract
Transmembrane integrin receptors represent a major component of cell-extracellular matrix
(ECM) communications that mediate cellular biological activities, including proliferation and
differentiation. Stem cells, especially mesenchymal stem cells (MSC), have rapidly emerged as
promising therapies for various diseases. Dynamic links exist between extracellular and intracellular
environments that profoundly influence the cellular activities via integrin receptors, such as cell
morphology transformation and differentiation. Interpreting the roles of integrin receptors in the
regulation of MSC differentiation may potentially lead to an amplified therapeutic effect. In this review,
we summarize, for the first time, the potential mechanisms by which integrins promote MSC
multilineage differentiation, including integrin downstream signaling cascades and the interactions
between integrin and ion channels, the cytoskeleton, and nuclear mechanoresponses. Furthermore,
we focus on the current state and future prospects of the application of integrins to promote cell differentiation.
Funder
Nature Science Foundation of Zhejiang Province
National Natural Science Foundation of China
Health Foundation of Zhejiang Province
Science and Technology Foundation
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
1 articles.
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