Integrin α6 (CD49f), The Microenvironment and Cancer Stem Cells-Reference-Cited by-同舟云学术

Integrin α6 (CD49f), The Microenvironment and Cancer Stem Cells

Published:2019-07-04 Issue:5 Volume:14 Page:428-436
ISSN:1574-888X
Container-title:Current Stem Cell Research & Therapy
language:en
Short-container-title:CSCR

Author:

Bigoni-Ordóñez Gabriele D.¹,Czarnowski Daniel²,Parsons Tyler²,Madlambayan Gerard J.²,Villa-Diaz Luis G.²

Affiliation:

1. Division de Investigacion Basica, Instituto Nacional de Cancerologia, Secretaria de Salud, Mexico City, Mexico

2. Department of Biological Sciences, Oakland University, Rochester, MI 48309, United States

Abstract

Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC populations in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnecting them with the tumorigenic microenvironment.

Funder

National Institutes of Health, NIH

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)

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