Retinal Tissue Engineering: Regenerative and Drug Delivery Approaches

Author:

Keshel Saeed Heidari12,Nadri Samad345,Aghmiuni Azadeh Izadyari6,Rahmani Ali3,Sefat Farshid78,Lashay Alireza9

Affiliation:

1. Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3. Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

4. Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

5. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.

6. Department of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.

7. Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, UK.

8. Interdisciplinary Research Centre in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, UK.

9. Translational Ophthalmology Research Centre (TORC), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Absatract: In recent decades, the improvement of photoreceptor/ cell transplantation has been used as an effective therapeutic approach to treat retinal degenerative diseases. In this reviwe, the effect of different factors on the differentiation process and stem cells toward photoreceptors along with cell viability, morphology, migration, adhesion, proliferation, and differentiation efficiency was discussed. It is no wonder that scientists are researching to better recognize the reasons for retinal degeneration, as well as discovering novel therapeutic methods to restore lost vision. In this field, several procedures and treatments in the implantation of stem cells-derived retinal cells have explored with some example of clinical trials. Although these clinical trials are too small to draw stable decisions about whether stem-cell therapies can offer a cure for retinal diseases. However, the future research directions have started for patients affected by retinal degeneration and promising findings have been obtained.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)

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