Affiliation:
1. Shanxi Medical University School and Hospital of Stomatology & Shanxi Province Key Laboratory of Oral Diseases
Prevention and New Materials, Taiyuan 030001, China
2. Central Laboratory, Peking University School and Hospital of
Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key
Laboratory of Digital Stomatology, Beijing, China
Abstract
Abstract:
Mesenchymal stem cells derived from postnatal orofacial tissues can be readily isolated and
possess diverse origins, for example, from surgically removed teeth or gingiva. These cells exhibit stem
cell properties, strong potential for self-renewal, and show multi-lineage differentiation, and they have
therefore been widely employed in stem cell therapy, tissue regeneration, and inflammatory diseases.
Among them, stem cells from human exfoliated deciduous teeth [SHED] and their derivatives have
manifested wide application in the treatment of diseases because of their outstanding advantages—
including convenient access, easy storage, and less immune rejection. Numerous studies have shown that
most diseases are closely associated with inflammation and that inflammatory diseases are extremely
destructive, can lead to necrosis of organ parenchymal cells, and can deposit excessive extracellular matrix
in the tissues. Inflammatory diseases are thus the principal causes of disability and death from many
diseases worldwide. SHED and their derivatives not only exhibit the basic characteristics of stem cells but
also exhibit some special properties of their own, particularly with regard to their great potential in inhibiting
inflammation and tissue regeneration. SHED therapy may provide a new direction for the treatment
of inflammation and corresponding tissue defects. In this review, we critically analyze and summarize the
latest findings on the behaviors and functions of SHED, serum‑free conditioned medium from SHED
[SHED-CM], and extracellular vesicles, especially exosomes, from SHED [SHED-Exos], and discuss
their roles and underlying mechanisms in the control of inflammatory diseases, thus further highlighting
additional functions for SHED and their derivatives in future therapies.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
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