The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives-Reference-Cited by-同舟云学术

The Emerging Role of microRNA in Periodontitis: Pathophysiology, Clinical Potential and Future Molecular Perspectives

Published:2022-06-17 Issue: Volume:17 Page:
ISSN:1574-888X
Container-title:Current Stem Cell Research & Therapy
language:en
Short-container-title:CSCR

Author:

Taheri Mohammad¹,Khoshbakht Tayyebeh²,Hussen Bashdar Mahmud³,Abdullah Sara Tharwat⁴,Ghafouri-Fard Soudeh⁵,Sayad Arezou⁶

Affiliation:

1. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2. Men\'s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq | Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq.

4. Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, Iraq.

5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

6. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Abstract: MicroRNAs [miRNAs] have been found to participate in the pathogenesis of several immune-related conditions through modulation of expression of cytokine coding genes and other molecules that affect activity of immune system. Periodontitis is an example of these conditions which has been associated with dysregulation of several miRNAs. Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. miR-146 is the mostly assessed miRNA in these patients being shown to be up-regulated in most conducted studies in patients with periodontitis. In the present review, we describe the impact of miRNAs dysregulation in the pathoetiology of periodontitis.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)

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