Affiliation:
1. Department of Spine Surgery, Honghui-Hospital, Xi’an Jiaotong University, School of Medicine, Xi’an, China
2. Department of Orthopedics, Hong Kong Baptist University School of Chinese Medicine, Hongkong, China
Abstract
Simvastatin, lovastatin, rosuvastatin, pravastatin and cerivastatin belong to the statin family,
which are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A. As the rate-limiting
enzyme in the pathway of cholesterol metabolism, statins are classically prescribed to patients as lipidlowering
agents. However, statins also possess several extra bioactivities, including anti-inflammatory,
antiviral and anti-tumor. Interestingly, the most essential mechanism of these activities is that statins
could regulate the expression of cell adhesion molecules (CAMs), especially, targeting lymphocytes
function-associated molecules (LFA)-1, macrophage (Mac)-1 and intercellular adhesion molecules
(ICAM)-1. Therefore, in this paper, we discussed the regulatory effect of statins on CAMs among different
diseases. In addition, we provided speculation for the role of statins in treating orthopedic disease.
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
4 articles.
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