Affiliation:
1. Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi, China
Abstract
The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular
proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing
of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation.
Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also
named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted
for in-depth exploring Cbl’s definite role during osteoclastogenesis, as well as its cross talking
with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current
study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of
Cbl, as well as its cross-talking in bone homeostasis.
Funder
Xi'an Science and Technology Bureau, Social Development Public Project
Shaanxi provincial Science and technology department, science and technology achievement transfer and promotion plan-award achievement transformation project, P.R. China
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
3 articles.
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