The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide’s Toxicity-Reference-Cited by-同舟云学术

The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide’s Toxicity

Published:2020-03-19 Issue:1 Volume:15 Page:18-23
ISSN:1574-888X
Container-title:Current Stem Cell Research & Therapy
language:en
Short-container-title:CSCR

Author:

Wang Youhan¹,Wang Biao¹,Yang Xiaobin¹

Affiliation:

1. Department of Spine Surgery, Honghui Hospital Affiliated to Xi’an Jiaotong University, Xi’an, China

Abstract

Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL.

Funder

Shaanxi Social Development Science and Technology Project

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)

Reference66 articles.

1. Tao X.; Younger J.; Fan F.Z.; Wang B.; Lipsky P.E.; Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study. Arthritis Rheum 2002,46(7),1735-1743

2. Tao X; Lipsky PE; The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum Dis Clin North Am 2000; 26(1): 29-50, viii. [viii.].

3. Han R.; Rostami-Yazdi M.; Gerdes S.; Mrowietz U.; Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br J Clin Pharmacol 2012,74(3),424-436

4. Liacini A.; Sylvester J.; Zafarullah M.; Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem Biophys Res Commun 2005,327(1),320-327

5. Ziaei S.; Halaby R.; Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review. Avicenna J Phytomed 2016,6(2),149-164

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