Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet Transplantation-Reference-Cited by-同舟云学术

Exosomal-microRNAs Improve Islet Cell Survival and Function In Islet Transplantation

Published:2024-07 Issue:5 Volume:19 Page:669-677
ISSN:1574-888X
Container-title:Current Stem Cell Research & Therapy
language:en
Short-container-title:CSCR

Author:

Minhua Qiu¹²,Bingzheng Feng²,Zhiran Xu²,Yingying Zhang³,Yuwei Yang¹²,Ting Zhang²⁴,Jibing Chen²⁴^ORCID,Hongjun Gao²⁴

Affiliation:

1. Graduate School, Guangxi University of Chinese Medicine, Nanning, China

2. Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, China

3. Department of Foreign Languages, Guangxi University of Chinese Medicine, Nanning, China

4. Guangxi Clinical Research Center for Kidney Diseases of Integrated Traditional Chinese and Western Medicine, Nanning, China

Abstract

Abstract: Exosomal-microRNAs (Exo-miRNAs) are key regulators of islet cell function, including insulin expression, processing, and secretion. Exo-miRNAs have a significant impact on the outcomes of islet transplantation as biomarkers for evaluating islet cell function and survival. Furthermore, they have been linked to vascular remodeling and immune regulation following islet transplantation. Mesenchymal stem cell-derived exosomes have been shown in preliminary studies to improve islet cell viability and function when injected or transplanted into mice. Overall, Exo-miRNAs have emerged as novel agents for improving islet transplantation success rates. The role of islet-derived Exo-miRNAs and mesenchymal stem cells-derived Exo-miRNAs as biomarkers and immunomodulators in islet regeneration, as well as their role in improving islet cell viability and function in islet transplantation, are discussed in this review.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine,Medicine (miscellaneous)