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  • Published:2021-11-22 Issue:2 Volume:14 Page:95-96
  • ISSN:1872-3128
  • Container-title:Drug Metabolism Letters
  • language:en
  • Short-container-title:DML

Author:

Yamazaki Hiroshi1

Affiliation:

1. Laboratory of Drug Metabolism and Pharmacokinetics Showa Pharmaceutical University Machida, Tokyo, Japan

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Biochemistry (medical),Clinical Biochemistry,Pharmaceutical Science

Reference22 articles.

1. Kamiya Y.; Handa K.; Miura T.; Yanagi M.; Shigeta K.; Hina S.; Shimizu M.; Kitajima M.; Shono F.; Funatsu K.; Yamazaki H.; In silico prediction of input parameters for simplified physiologically based pharmacokinetic models for estimating plasma, liver, and kidney exposures in rats after oral doses of 246 disparate chemicals. Chem Res Toxicol 2021,34(2),507-513

2. Miura T.; Uehara S.; Shigeta K.; Yoshizawa M.; Kamiya Y.; Murayama N.; Shimizu M.; Suemizu H.; Yamazaki H.; Metabolic profiles of tetrabromobisphenol A in humans extrapolated from humanized-liver mouse data using a simplified physiologically based pharmacokinetic model. Chem Res Toxicol 2021,34(2),522-528

3. Taniguchi-Takizawa T.; Kato H.; Shimizu M.; Yamazaki H.; Predicted contributions of flavin-containing monooxygenases to the N-oxygenation of drug candidates based on their estimated base dissociation constants. Curr Drug Metab 2021,22(3),208-214

4. Kamiya Y.; Omura A.; Hayasaka R.; Saito R.; Sano I.; Handa K.; Ohori J.; Kitajima M.; Shono F.; Funatsu K.; Yamazaki H.; Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning. Biochem Pharmacol 2021,192

5. Uraoka M.; Shimizu M.; Kuwajima Y.; Mizugaki A.; Yokoyama H.; Mure K.; Yamazaki H.; Different effects of polymorphic flavin-containing monooxygenase 3 and cytochrome P450 2A6 activities on an index of arteriosclerosis as a lifestyle-related disease in a general population in Japan. Curr Drug Metab 2020,21(14),1161-1164
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