Affiliation:
1. Central Facility of Instrumentation, Faculty of Pharmacy, IFTM University, Moradabad, 244001, Uttar Pradesh, India
Abstract
Background:
Currently, ringworm treatment drugs include two major categories: first, propylene
amine drugs, such as terbinafine, butenafine and naftifine, which exert their bactericidal effects
through inhibiting squalene cyclase, causing the lack of ergosterol and accumulation of squalene. The
second category of imidazole drugs includes miconazole, econazole, clotrimazole, ketoconazole and
bifonazole.
Mechanism:
These synthetic antifungal agents exhibits their action by inhibiting the lanosterol 14α-
demethylation activity of fungal cell, leading to the prevention of the ergosterol synthesis of cell membrane,
changing the cell membrane permeability, and resulting in the loss of important intracellular fungal
material and causing fungal death.
Applications:
At present, Imidazole antifungal agents are commonly used drugs in clinical treatment of
ringworm with extensive clinical applications.
Conclusion:
The present review covers the chemistry and detailed pharmacology aspects of luliconazole.
Publisher
Bentham Science Publishers Ltd.
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference48 articles.
1. Uchida K.; Nishiyama Y.; Yamaguchi H.;
In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother 2004,10(4),216-219
2. Scher R.K.; Nakamura N.; Tavakkol A.; Luliconazole: A review of a new antifungal agent for the topical treatment of onychomycosis. Mycoses 2014,57(7),389-393
3. Sahoo A.K.; Mahajan R.; Management of Tinea corporis, Tinea cruris, and Tinea pedis: A comprehensive review. Indian Dermatol Online J 2016,7(2),77-86
4. Humera Q.F.A.; Sultana Q.; Siddiqui M.A.W.; Epidemiology of dermatophytic infections with evaluation of efficacy and safety of luliconazole cream 1% versus miconazole 2% cream- A randomized two-group study. Int J Bio Pharm Res 2015,6(5),359-363
5. Watanabe S.; Takahashi H.; Nishikawa T.; Takiuchi I.; Higashi N.; Nishimoto K.; Kagawa S.; Yamaguchi H.; Ogawa H.; A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for Tinea pedis. Mycoses 2006,49(3),236-241
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献