A Review on Synthesis, Anticancer and Antiviral Potentials of Pyrimidine Derivatives

Abstract

Background: Pyrimidine is the six membered heterocyclic aromatic compound similar to benzene and pyridine containing two nitrogen atoms at 1st and 3rd positions. Pyrimidine is present throughout nature in various forms and is the building blocks of numerous natural compounds from antibiotics to vitamins and liposacharides. The most commonly recognized pyrimidines are the bases of RNA and DNA, the most abundant being cytosine, thymine or uracil. Results: Pyrimidine is a core structure in a wide variety of compounds that exhibits significant biological activity and also plays an important role in the drug discovery process. Various synthetic aspects indicated that pyrimidine derivatives are easy to synthesize and has diverse biological and chemical applications. The present review article aims to review the work reported on synthesis, anticancer and antiviral potentials of pyrimidine derivatives during new millennium. Conclusion: It may be concluded that the fused pyrimidine derivatives enhanced the anticancer potential against different human cancer cell lines and antiviral potential against different human immunodeficiency virus (HIV), herpes simplex virus (HSV-1) etc, which created interest among the medicinal chemists in the pyrimidine skeleton in medicinal chemistry. Thus, a tremendous scope for research is present in this direction for investigating pyrimidine derivatives as lead molecules.