Extraction and Purification of Bioactive Peptide with Antimicrobial Properties from Horseshoe Crab

Author:

Oli Ajay Kumar1,Shivshetty Nagaveni2,Javaregowda Palaksha Kanive1,Revanna Kelmani Chandrakanth3

Affiliation:

1. Department of Biomedical Science, SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, 5th Floor, Manjushree Building, SDM College of Medical Sciences & Hospital Campus Sattur, Dharwad-580009, Karnataka, India

2. Department of Microbiology/Food Science and Technology, GITAM Institute of Sciences, GITAM (Deemed to be University), Gandhi Nagar, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India

3. Department of Biotechnology, Jnana Ganga Campus, Gulbarga University Kalaburagi, Karnataka 585106, India

Abstract

Abstract: Peptides are small biomolecules that act as bioactive or host defense molecules. These peptides have a significant role in medicine because of their broad spectrum antimicrobial properties. Marine sources are the largest supply of peptides and natural small molecules since they represent half of the total global biodiversity. Among the different crab species, the horseshoe crab is widely used for extracting the peptides. The horseshoe crab is a marine and brackish water arthropod; it plays a crucial role in the reel and whelk fishing industry and the production of important pharmaceutical bioactive components. This review highlights the details of the extraction and purification of antimicrobial peptides from the horseshoe crab. These peptides represent trends and opportunities for the future, with a focus on the pharmaceutical industries.

Publisher

Bentham Science Publishers Ltd.

Subject

General Pharmacology, Toxicology and Pharmaceutics

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