Affiliation:
1. School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India-686560
2. Post graduation and Research
Department of Botany, Govt. Arts Autonomous College, Coimbatore-641018, Tamil Nadu, India
Abstract
Background:
The Adiantum lunulatum is a medicinally important pteridophyte used to treat inflammatory-related diseases. The phytochemical profile of this plant is poorly investigated.
Objective:
Here, we screened the nonpolar phytochemicals and their interactions with cyclooxygenase 2 (COX-2) enzyme (inflammation), transient receptor potential cation channel V member 1 (TRPV1), and transient receptor potential channel 3 (TRPC3) receptors (pain).
Methods:
The identification and molecular docking analysis used gas chromatography-mass spectrometry (GC-MS), AutoDock Vina, and BIOVIA discovery studio visualizer 2020. The online computer tools Swiss ADME and admetSAR predicted these compounds' bioavailability and toxicity.
Results:
GC-MS analysis detected the 12 different compounds. Five compounds with high similarity to mass spectrum were selected for molecular docking. This includes 2, 4 di-tert-butylphenol; n-hexadecanoic acid (palmitic acid); 2 pentadecanone, 6, 10, 14-trimethyl-; Quinoline 1, 2 dihydro 2, 2, 4 trimethyl and 3, 7, 11, 15-tetramethyl hexadec 2-en-1-yl acetate. These compounds showed interaction with the binding pocket of COX-2, TRPV1, and TRPC3 proteins. This interaction with enzyme and receptor activity causes a reduction in inflammatory pathogenesis.
Conclusion:
This study enhances our fundamental knowledge of biologically important volatile phytochemicals in Adiantum lunulatum dichloromethane extract and its possible effects in reducing inflammatory responses.
Publisher
Bentham Science Publishers Ltd.
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference40 articles.
1. Srivastava T.N.; Rajasekharan S.; Badola D.P.; Shah D.C.; An index of the available medicinal plants, used in Indian system of medicine from jammu and Kashmir state. Anc Sci Life 1986,6(1),49-63
2. Jain A.; Katewa S.S.; Galav P.K.; Sharma P.; Medicinal plant diversity of sitamata wildlife sanctuary, Rajasthan, India. J Ethnopharmacol 2005,102(2),143-157
3. Kamble M.Y.; Mane S.S.; Murugan C.; Jaisankar I.; Diversity of ethnomedicinal plants of tropical islands - with special reference to Andaman and Nicobar islandsBiodiversity and Climate Change Adaptation in Tropical Islands; Sivaperuman, C; Velmurugan, A; Singh, AK 2018,55-103
4. Zheng X.; Xing F.; Ethnobotanical study on medicinal plants around Mt. Yinggeling, Hainan Island, China. J Ethnopharmacol 2009,124(2),197-210
5. Zheng X.; Wei J.; Sun W.; Li R.; Liu S.; Dai H.; Ethnobotanical study on medicinal plants around Limu Mountains of Hainan Island, China. J Ethnopharmacol 2013,148(3),964-974
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献