Pharmacokinetics-based Chronotherapy-Reference-Cited by-同舟云学术

Pharmacokinetics-based Chronotherapy

Published:2022-01 Issue:1 Volume:23 Page:2-7
ISSN:1389-2002
Container-title:Current Drug Metabolism
language:en
Short-container-title:CDM

Author:

Lu Danyi¹^ORCID,Wang Zhigang²,Wu Baojian¹

Affiliation:

1. Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China

2. Department of Intensive Care Unit, First Affiliated Hospital of Jinan University, Guangzhou, China

Abstract

Abstract: Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long recognized. Studies in recent years have revealed that daily rhythmicity in expression of drug-metabolizing enzymes and transporters (DMETs) are key factors determining chronopharmacokinetics. In this article, we briefly summarize current knowledge with respect to circadian mechanisms of DMETs and discuss how rhythmic DMETs are translated to drug chronoeffects. More importantly, we present our perspectives on pharmacokinetics-based chronotherapy.

Funder

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

Project of Administration of Traditional Chinese Medicine of Guangdong Province of China

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Pharmacology

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