Affiliation:
1. Department of Chemistry, National Cheng Kung University, Tainan, Taiwan
2. Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan
Abstract
Background:
The curcumin-C3 (cur-C3) complex obtained from Curcuma longa rhizome is a combination
of three curcuminoids, namely, curcumin, dimethoxycurcumin, and bisdemethoxycurcumin. Cur and curcuminoids
have been extensively researched for their wide range of therapeutic properties against inflammatory diseases,
diabetes, and cancer.
Objective:
In spite of their extensive medicinal properties, cur and curcuminoids have poor solubility and bioavailability
due to their hydrophobicity. This limitation can be overcome by complexing cur-C3 with natural cyclic oligosaccharides,
such as Cyclodextrin (CD).
Methods:
In this study, cur-C3 and CD (α, β) inclusion complexes (ICs) were prepared with different molar ratios
and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray diffraction, and
transmission electron microscopy.
Results:
The cur-C3 cyclodextrin ICs showed an increased entrapment efficiency of 97.8% and improved antioxidant
activity compared to cur and can be used as an antioxidant to reduce cancer-related oxidative stress. Additionally, α-
CD ICs of curcumin-C3 caused an increase in growth inhibition of Staphylococcus aureus.
Conclusion:
Our findings suggest that both α- and β-CDs are suitable carriers for cur-C3 and can be used as an effective
treatment for cancer-associated oxidative stress and as a preventive treatment for nosocomial infections and
pneumonia.
Funder
National Cheng Kung University
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology
Cited by
13 articles.
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