Affiliation:
1. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4349 Martin Luther King Boulevard, Houston, Texas, 77204, United States
2. Department of Pharmaceutical Science, College of Pharmacy and Health
Sciences, Texas Southern University, 3100 Cleburne Street, Houston, Texas, 77004, United States
3. Taihe Hospital, Hubei University
of Medicine, 32 South Renmin Road, Shiyan, Hubei, 442000, China
Abstract
Background:
Chemotherapeutic drugs used in cancer treatment often result in gastrointestinal toxicity,
notably diarrhea, impacting patients’ quality of life. Complementary and Alternative Medicine (CAM) has garnered
increasing interest as an alternative to conventional approaches as a potential solution for managing chemotherapyinduced
diarrhea (CID).
Objective:
To summarize current research focusing on herbal medicines as adjuvant therapy to prevent or treat
chemotherapy-induced diarrhea, including clinical assessments, mechanism of actions, active components, and potential
pharmacokinetic interactions between herbal medicines and chemotherapeutic drugs.
Methods:
We performed the literature review from PubMed, CNKI, Google Scholar, Web of Science, and Scopus
using “Chemotherapy”, “Diarrhea,” and “Complementary and Alternative Medicine” as the search keywords.
Results:
Using herbal medicines as adjuvants provides an effective approach to treating or preventing CID with
improved or unaffected antitumor activity of chemotherapeutic drugs. Among these herbal formulations, scutellaria,
ginger, and ginseng are the most frequently used herbs in the prescriptions for CID. The main antidiarrheal components
in herbs include wogonin, baicalin, chrysin, quercetin, gingerol, and ginsenosides. These herbs, formulations,
and bioactive components relieved CID through different mechanisms, including directly decreasing local drug exposure,
anti-inflammation, inhibiting epithelial apoptosis, or promoting epithelium stem cell regeneration. The application
of herbal medicines as adjunctive therapies showed efficacy in preventing or treating CID in multiple clinical
trials. However, more well-designed clinical studies are expected to validate the results further. Despite some clinical
studies demonstrating that certain herbal medicines could potentially attenuate CID and improve efficacy, it remains
necessary to evaluate herbal safety. The interactions between herbs and drugs are also potential concerns, but few
clinical trials have focused on investigating this aspect.
Conclusion:
In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities
induced by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate
their efficacy, ensure safety, and explore potential drug-herb interactions.
Funder
National Cancer Institute
National Natural Science Foundation of China
National Institute of General Medical Sciences
Cancer Prevention Research Institute of Texas
Natural Science Foundation of Hubei Province of China
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology