Affiliation:
1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,
Sichuan University, Chengdu 610041, China
Abstract
Background:
Nucleic acid is a genetic material that shows great potential in a variety of biological applications.
With the help of nanotechnology, the fabrication of DNA-based nanomaterials has emerged. From genetic
DNA to non-genetic functional DNA, from single-layer and flat structure to multi-layer and complex structure, and
from two-dimensional to three-dimensional structure, DNA-based nanomaterials have been greatly developed, bringing
significant changes to our lives. In recent years, the research of DNA-based nanomaterials for biological applications
has developed rapidly.
Methods:
We extensively searched the bibliographic database for a research article on nanotechnology and immunotherapy
and further discussed the advantages and drawbacks of current DNA-based nanomaterials in immunotherapy.
By comparing DNA-based nanomaterials with traditional biomaterials applied in immunotherapy, we found that
DNA-based nanomaterials are a promising candidate material in Immunotherapy.
Results:
Due to the unrivaled editability and biocompatibility, DNA-based nanomaterials are not only investigated as
therapeutic particles to influence cell behavior but also as drug delivery systems to treat a variety of diseases. Moreover,
when DNA-based nanomaterials are loaded with therapeutic agents, including chemical drugs and biomolecules,
which significantly enhance the therapeutic effects, DNA-based nanomaterials have great potential in immunotherapy.
Conclusion:
This review summarizes the structural development history of DNA-based nanomaterials and their
biological applications in immunotherapy, including the potential treatment of cancer, autoimmune diseases, and
inflammatory diseases.
Funder
National Key R&D Program of China
National Natural Science Foundation of China
China Postdoctoral Science
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology
Cited by
1 articles.
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