Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease:
A Current Update on Preclinical Evidence
Author:
Moon Changjong1,
Weerasinghe-Mudiyanselage Poornima D.E.1,
Kang Sohi1,
Kim Joong-Sun1
Affiliation:
1. Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR Program,
Chonnam National University, Gwangju 61186, South Korea
Abstract
Abstract:
Despite being classified as a movement disorder, Parkinson’s disease (PD) is characterized
by a wide range of non-motor symptoms that significantly affect the patients' quality of life. However,
clear evidence-based therapy recommendations for non-motor symptoms of PD are uncommon. Animal
models of PD have previously been shown to be useful for advancing the knowledge and treatment
of motor symptoms. However, these models may provide insight into and assess therapies for
non-motor symptoms in PD. This paper highlights non-motor symptoms in preclinical models of PD
and the current position regarding preclinical therapeutic approaches for these non-motor symptoms.
This information may be relevant for designing future preclinical investigations of therapies for nonmotor
symptoms in PD.
Funder
National Research Foundation (NRF) of Korea by the Korean Government
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
2 articles.
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