Affiliation:
1. Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Abstract
Background:
Pharmacological treatment for alcohol dependence has only three approved
drugs: disulfiram, naltrexone and acamprosate. The effects of these drugs are, however, limited,
presenting several side effects and a modestly higher efficacy compared to placebo. The administration
of omega-3 might bring new perspectives to relapse prevention.
Methods:
This systematic review aimed to analyze the available literature, compiling the studies
that used omega-3 to prevent relapse in alcohol dependents.
Results:
The databases used were PubMed and Web of Science. We identified 2,231 studies and
only five articles addressed the administration of omega-3 and alcoholism. Preclinical studies
evaluating the effects of PUFAs related to chronic alcohol administration showed improvements in
behavioral, cellular and molecular levels. The clinical trial yielded inconclusive results.
Conclusion:
Despite the reduced number of studies, omega-3 interventions seem to be promising
for controlling issues related to alcohol dependence.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
6 articles.
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