Affiliation:
1. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 3 Lenin Av., Tomsk 634028, Russian Federation
2. Siberian State Medical University, Tomsk, Russian Federation
Abstract
The use of neuroprotective agents for stroke is pathogenetically justified, but the translation
of the results of preclinical studies of neuroprotectors into clinical practice has been a noticeable
failure. One of the leading reasons for these failures is the one-target mechanism of their activity.
p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as
olive oil and wine. Tyr has a wide spectrum of biological activity: antioxidant, stress-protective,
anti-inflammatory, anticancer, cardioprotective, neuroprotective and many others. This review analyzes
data on the neuroprotective, antioxidant, anti-inflammatory, anti-apoptotic and other kinds of
Tyr activity as well as data on the pharmacokinetics of the substance. The data presented in the
review substantiate the acceptability of tyr as the basis for the development of a new neuroprotective
drug with multitarget activity for the treatment of ischemic stroke. Tyr is a promising molecule
for the development of an effective neuroprotective agent for use in ischemic stroke.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
18 articles.
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