Neuroinflammation: The Role of Anthocyanins as Neuroprotectants-Reference-Cited by-同舟云学术

Neuroinflammation: The Role of Anthocyanins as Neuroprotectants

Published:2022-11 Issue:11 Volume:20 Page:2156-2174
ISSN:1570-159X
Container-title:Current Neuropharmacology
language:en
Short-container-title:CN

Author:

Banji Otilia J.F.¹,Banji David²,Makeen Hafiz A.¹,Alqahtani Saad S.¹,Alshahrani Saeed²

Affiliation:

1. Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan, KSA

2. Department of Pharmacology & Toxicology, College of Pharmacy, Jazan University, Jazan, KSA

Abstract

Abstract: Neuroinflammation is a trigger for several neurodegenerative and neuropsychiatric disorders. Exposure to noxious external stimuli induces homeostatic disturbances resulting in morphological changes in microglia, their activation, and elaboration of pro-inflammatory mediators. This leads to neuroinflammation with the progressive loss of neurons. Nutraceuticals such as anthocyanins are a class of brightly colored bioactive compounds present in fruits and vegetables with purported health benefits. They interfere with the activation of several signaling cascades that have a prominent role in preventing neuroinflammation. More importantly, anthocyanins can cross the blood-brain barrier and are safe. Hence, the current review focuses on the bioavailability of anthocyanins, clinical and in vitro evidence on their role in impeding the activation of transcription factors, modulating the immune milieu within the central nervous system, preventing the activation of microglia, and averting neuroinflammation.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine

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