Affiliation:
1. Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, Uttar Pradesh, India
Abstract
Abstract:
SARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission
led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its
antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO
are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase
appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell
destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of
COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe
form.
Publisher
Bentham Science Publishers Ltd.
Subject
Infectious Diseases,Virology,Pulmonary and Respiratory Medicine,Immunology and Microbiology (miscellaneous)