The Several Activities of 4 - Methyl Pyrazole in Animals and Humans
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Published:2018-09-12
Issue:18
Volume:24
Page:1957-1960
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ISSN:1381-6128
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Container-title:Current Pharmaceutical Design
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language:en
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Short-container-title:CPD
Affiliation:
1. Gastroenterology and Digestive Endoscopy Service, S. Rita Clinic, via Appia, 83042, Atripalda, Italy
Abstract
4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than
toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene
glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective
effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first
time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal
injury.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology