Affiliation:
1. Department of Pharmacy, Jagannath University, Sadarghat, Dhaka-1100, Bangladesh
2. Department of Pharmacy, Southeast University, Banani, Dhaka-1213, South Korea
Abstract
Aging is a normal human cycle and the most important risk factor for neurodegenerative diseases.
Alternations in cells due to aging contribute to loss of the nutrient-sensing, cell function, increased oxidative
stress, loss of the homeostasis cell, genomic instability, the build-up of malfunctioning proteins, weakened cellular
defenses, and a telomere split. Disturbance of these essential cellular processes in neuronal cells can lead to
life threats including Alzheimer's disease (AD), Huntington's disease (HD), Lewy's disease, etc. The most common
cause of death in the elderly population is AD. Specific therapeutic molecules were created to alleviate AD’s
social, economic, and health burden. In clinical practice, almost every chemical compound was found to relieve
symptoms only in palliative treatment. The reason behind these perfect medicines is that the current medicines are
not effective in targeting the cause of this disease. In this paper, we explored the potential role of flavonoid and
polyphenolic compounds, which could be the most effective preventative anti-Alzheimer 's strategy.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
25 articles.
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