Heart Failure in Diabetes Mellitus: An Updated Review-Reference-Cited by-同舟云学术

Heart Failure in Diabetes Mellitus: An Updated Review

Published:2020-12-30 Issue:46 Volume:26 Page:5933-5952
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Sohrabi Catrin¹^ORCID,Saberwal Bunny²^ORCID,Lim Wei-Yao²^ORCID,Tousoulis Dimitris³^ORCID,Ahsan Syed²^ORCID,Papageorgiou Nikolaos²^ORCID

Affiliation:

1. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

2. Electrophysiology Department, Barts Heart Centre, St. Bartholomew’s Hospital, West Smithfield, London, United Kingdom

3. First Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece

Abstract

Diabetes mellitus (DM) and heart failure (HF) are comorbid conditions associated with significant morbidity and mortality worldwide. Despite the availability of novel and effective therapeutic options and intensive glycaemic control strategies, mortality and hospitalisation rates continue to remain high and the incidence of HF persists. In this review, we described the impact of currently available glucose-lowering therapies in DM with a focus on HF clinical outcomes. Non-conventional modes of management and alternative pathophysiological mechanisms with the potential for therapeutic targeting are also discussed.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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