Affiliation:
1. Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro”, Bari, Italy
Abstract
Background:
MiRNAs are a class of small non-coding RNAs that are involved in the post-transcriptional
regulation of gene expression. MiRNAs are considered a class of epigenetic biomarkers. These biomarkers
can investigate disease at different stages: diagnosis, therapy or clinical follow-up.
Objective:
The aim of this paper is to highlight the innovative use of miRNAs in several childhood diseases.
Methods:
We conducted a literature review to search the usage of miRNAs in pediatric clinical routine or experimental
trials.
Results:
We found a possible key role of miRNAs in different pediatric illnesses (metabolic alterations, coagulation
defects, cancer).
Conclusion:
The modest literature production denotes that further investigation is needed to assess and validate
the promising role of miRNAs as non-invasive biomarkers in pediatric disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
4 articles.
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